Enter study data manually

Below are the manual steps for entering study data into RevMan. This can be a good approach if you have a smaller number of studies and results. If you have a larger data set, using the CSV import will likely be more efficient. Click the Studies section in the left-hand navigation and select Included studies.

1. Enter general information

On the ‘General’ tab, you can edit the Study ID, year of publication and the data source

2. Edit study reference

On the 'References' tab, click on the arrow icon to reveal the reference, then click on the 'Edit' button. If you have more than one report of an included study, see How to mark a report as a primary reference. You can remove the reference by clicking the 'Delete' button.

3. Enter study characteristics

In the ‘Characteristics’ tab you can edit the description of the characteristics of the included study.

3.a Paste study characteristics

In the ‘Characteristics’ tab you can paste the description of the characteristics of the included study that you have copied from a table on an external source. The external source could e.g. be a webpage, a Word document or a spreadsheet.

Please ensure you tag a version on the Review Dashboard before editing any characteristics, as pasting will override any text already in the text boxes.

Copy the table (horizontal or vertical) from an external source and click the 'Paste all' button at the bottom of the ‘Characteristics’ tab. Your browser may ask you to allow RevMan to access your clipboard. Please click 'Allow' to use this feature.

Please note the formatting that will be copied:

• Word: paragraphs italics, bold, underline and links are supported
• Spreadsheets: links and paragraphs are supported
• Web page: depend on tags used (italics, bold, underline and links are supported)

4. Enter result data

4.a Enter the study's intervention arms

The study you are entering data for has three intervention arms: Xibornol, Tetracycline and Placebo. The former two intervention arms correspond to the 'Antibiotics' intervention you defined in the first step, while the latter corresponds to the Placebo intervention. You could choose to combine the first two arms manually, but it's better to let RevMan do this so that you have a record of the original extracted data.

Go to the Study arm tab. Click Add Arm and choose 'Antibiotics' as the Intervention. For the Name, enter 'Xibornol' (overwriting the default name provided by RevMan). 

Add the second arm by clicking Add Arm, and choose 'Antibiotics' as the Intervention again. For the Name, enter 'Tetracycline'. Finally, click Add Arm a third time and choose 'Placebo' as Intervention. Leave the default Name as it is.

4.b Enter the study's result data

After you have entered the study arms, go to the Result Data tab.

Click Add result and select the outcome that you defined earlier 'Persistent symptoms after 7 days' from the Outcome list and select what type of results data you will be entering: arm-level or contrast-level and click OK. 

Adding a result will generate a table with one row for each of the study arms, and columns where you can enter the required result data.

In this case with arm-level data, it’s number of Events (participants with symptoms) and the Total (sample size) for each arm.

For Placebo, enter Events 51 and Total 155.
For Aureomycin, enter Events 39 and Total 154.

When adding a Result for contrast-level data, you will also need to specify the effect measure and reference arm.

In this case with contrast-level data, it’s logOdds ratio and standard error for each contrast.

(Tetracycline vs Placebo): logOdds ratio -3.5 and the standard error 0.5
(Xibornolics vs Placebo): logOdds ratio -1.2 and the standard error 1

Move between the included studies to add the Study Arms and Results data analysis for each using the navigation arrows.

4.c Add covariates to studies

If you predefined covariates for subgroup and sensitivity analyses (in Step 1), assign the relevant covariate categories to each included study. 

The restriction is however that the studies only report one result per covariate in order to assign it. Currently, this is the only type of subgrouping and sensitivity analyses you can do with study centric data management. 

Assuming that all of our (already defined) studies fall into one of the two categories, go to the Covariate tab (still within the Included studies). You will see all your predefined covariates listed with dropdown options for the different predefined categories.

Move between the included studies to add Covariates for each using the Previous and Next navigation arrows.

5. Enter Risk of Bias assessment (Risk of Bias 1)

To edit the 'Risk of Bias' assessment, open an included study, click on the 'Edit Study' button, then click on the 'Risk of Bias' tab to make a judgement about the Risk of Bias for each domain.

You can also enter text to support your judgement. To edit the Risk of Bias items (domains) see Risk of Bias 1.

6. Enter Risk of Bias 2 data

6.a Enter Risk of Bias 2 data (not using study-centric data)

In the Analyses, go to the analysis (outcome) where you want to add your judgement, then click on 'Edit Analysis'.

If the outcome in this Analysis was pre-specified in the protocol for a Risk of Bias 2 assessment, ensure the ‘Show the Risk of Bias table’ box is checked in the ‘Options’ tab.

This will create a results-level Risk of Bias table for this Analysis, which includes all domain judgements and support for judgements for this outcome (see Step 5 on ‘Set up an Analysis’).

6.b Go to Risk of Bias judgements

To add a Risk of Bias judgement for a particular result, click on the 'Action' button on each study row and select 'Edit Risk of Bias'.

6.c Enter the Risk of Bias judgements

For each domain, make a judgement (low Risk of Bias, some concerns, or high Risk of Bias) and add supporting text. This information populates the results-level, RoB 2 tables and therefore must be completed.
If the support for judgement text is not included this will raise a Validation Error in the Dashboard.

Please ensure you include the correct information in the support for judgement text box in RevMan.

At the moment this needs to be done manually, i.e. there is no way to automatically transfer these judgements from a file or an application.

As mentioned before, the first domain (Bias arising from the randomization process) is study-level and all changes made for this domain will apply to all results within the study.

6.d View the Risk of Bias summary graph

To view the graph summary of your Risk of Bias judgements, go back to the analysis and click on the 'Graphs' tab. 

Tick the box in front of 'Show Risk of Bias summary' and then the Risk of Bias traffic lights will be added to the forest plot in the associated Analysis section of the published review. There is no need to create figures from an Analysis as you can reference the relevant Analysis within the review text.

The results for which you have not entered the Risk of Bias judgements are indicated by orange circles with exclamation marks.

Please do not create the automated Risk of Bias figures in the Figures section of your review as these are only meant to be used with Risk of Bias 1 and are likely to be too large to publish.

6.e View the Risk of Bias table

Each outcome prespecified for RoB 2 assessments (likely to be the reviews’ critical and important outcomes included in the SoF table) should have a table that includes the Risk of Bias judgements (high, low or some concerns) and the supporting text for each judgement. 

Once you have created the main Analysis, added the Risk of Bias assessments and ticked 'show Risk of Bias table' in the analysis options, you can view a version to see the Risk of Bias table. 

In the generated view, scroll down to the ‘Risk of Bias’ section to view the results-level RoB 2 tables, which are located after the characteristics of studies section. The tables will only include the author judgements and support for judgements in text form, it is not possible to view the final table as it will be published in the Cochrane Library where the author judgements show as colour coded symbols linked to the support for judgement.

Please do not create the automated Risk of Bias figures in the Figures section of your review as these are only meant to be used with Risk of Bias 1 and are likely to be too large to publish. 

6.f Duplicating the Analysis for a sensitivity or subgroup analyses that include the Risk of Bias assessments 

Once you have created the main Analysis and added the Risk of Bias assessments, you can duplicate this for the sensitivity or subgroup analysis. This prevents you from needing to re-input the data and Risk of Bias assessments. To duplicate, select the Analysis and go to ‘Actions’. Select ‘Duplicate Analysis’ and select the destination analysis group.

Please note that it is not possible to store two sets of RoB 2 assessments for a single study, if for instance, a study with two subgroups has different RoB 2 assessments for each of the subgroups. There will be only one set of RoB 2 judgements available per subgroup.

The duplicated Analysis will be added below your main Analysis.

Select the new Analysis. You can change the name of the Analysis in the ‘Options’ tab and remove the studies that you don’t want to be included in that sensitivity analysis in the ‘Data’ tab by selecting ‘Delete data row’ under ‘Actions’.

There is more information in this Knowledge Base on ‘sensitivity analysis’ and ‘subgroup analysis’.

6.g Delete a Risk of Bias assessment

If there is an analysis or study for which you would like to remove the Risk of Bias assessment, there are two ways to do this. 

If you do not want a Risk of Bias assessment to publish for a full Analysis, you can uncheck the "Show Risk of Bias table" for that Analysis.

If you want to delete the Risk of Bias assessment for a particular study (e.g., if you copied created the analysis by duplicating another analysis for which Risk of Bias was already determined, but it is not relevant for that analysis), you can select the study, click on the Action menu, and select Delete Risk of Bias.