Serious error in a Cochrane Review. Following the conclusions of the published review could result in harm to patients or populations of interest (other than known adverse effects); and/or there are factual errors in describing one or more included studies that risk misinforming implementation or investment decisions about an intervention; and/or the reported treatment effect is inconsistent with the real effect shown in the reported data. Also see Serious errors in published Cochrane Reviews.
Confirmed serious error in a Cochrane Review as a direct result of the retraction of an included study. This could occur if studies included in a Cochrane Review are retracted from publication, and an analysis shows that the removal of the retracted studies from the analyses in the Cochrane Review could lead to a serious error (defined above). Also see Serious errors in published Cochrane Reviews.
Scientific misconduct in the Cochrane Review. This could refer to fraud or other scientific misconduct in the preparation of the review.
Serious breach of Cochrane’s conflict of interest policy. A ruling by Cochrane’s Funding Arbiters that a Cochrane Review has seriously breached Cochrane’s conflict of interest policy.