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  • Methodological queries, concerns, or uncertainty.
  • Support for rejection (see rejection policy).
  • Complex methods and the CRG does not otherwise have access to appropriate methodological support (e.g. from the NIHR Complex Reviews Support Unit).
  • Any potential conflict of interest of editorial staff (e.g. if the Co-ordinating Editor and/or Managing Editor is an author). Sign-off for publication to be provided by Network Senior Editor.
  • When multiple iterations have been made and an independent perspective is required (a "fresh pair of eyes").

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  • Red flags from the abstract (stage E alert) identified by the Senior or Associate Editor or via the weekly Analysis of Review Group Output (ARGO) meeting held by UK Cochrane Centre.
  • Occasional referrals from Copy Edit Support or via Cochrane Clinical Answers.
  • Critical feedback, retracted studies, or comments received after publication.

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