General information
Annotation widget
- We have imported the annotation widget, that we use for systematic review annotation, in to the CRS Web
- If you cannot access the CRS Web please contact Deirdre Beecher
COVID-19 Register in CRS Web
- The register will be listed with any other registers that you access via the CRS Web
- Search and layout is identical to that in other CRS registers
Annotation status & fields
- Additional fields have been added to the CRS records to assist us in our workflow
- Three annotation status are available
Annotation detail required
Population/Condition | Intervention | Comparator | Outcomes |
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Not possible to complete the full annotation?
In some cases you will not be able to complete a full annotation. We ask that you:
- mark the annotation as Complete
- in the Annotation Action field in the CRS record select Vocabulary Request
- in the Annotation Notes field take note of the term requested
- request the missing term(s) in the Slack channel alerting Anna Last
- as soon as requested term(s) are available modify the annotation
- remove Vocabulary Request action
Priority studies to annotate
Important!
These may change over time depending on topics to be coved in rapid reviews.
Highest Priority
Intervention Assignment: Randomised and:
Any of the following interventions:
- Hand cleaning with ash
- Convalescent plasma, convalescent serum or convalescent hyperimmune immunoglobulin
- Any intervention in which a core component involves the use of the internet to facilitate video calls or video conferencing through computers, smartphones or tablets
- chloroquine, remdesivir, or corticosteroids
Priority 2
Intervention Assignment: Non-randomised or Unclear or Quasi-randomised and:
Any of the following interventions:
- Hand cleaning with ash
- Convalescent plasma, convalescent serum or convalescent hyperimmune immunoglobulin
- Any intervention in which a core component involves the use of the internet to facilitate video calls or video conferencing through computers, smartphones or tablets
- chloroquine, remdesivir, or corticosteroids
Searching the backlog on https://covid-19.cochrane.org/ to identify priority trials
Restrict to Study Type: Interventional
For the specific interventions:
- Text search for ash*
- Text search for convalescent
- Separate text searches for video, loneliness, "social isolation"
- Separate text searches for chloroquine, remdesivir,
Topics/vocabulary
- Before you start annotating please check that the Cochrane Linked Data Vocabulary to determine whether or not terms are available
- If not available, place your request in the covid19-study-annotation channel in Slack and alert Anna last
Vocabulary notes
Age
A number of studies will state in their inclusion criteria Aged 18 years or older. Please annotate as:
Young Adult 19-24 years or Adult 19-44 years or Middle Aged 45-64 years or Aged 65-79 years or Aged 80 and over 80+ years |
Drug combinations
Use the individual drugs with AND
At Risk Of
In some studies the inclusion criteria population is 'At risk of ...' - in this case we do not annotate the condition in the Population but only as an Outcome
Table of misc. terms and their categories
PICO | Topic | Domain Term | Category |
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I/C | Usual Care | Usual Care | Other |
I/C | Western Medicine | Usual Care | Pharmacological |
I/C | Symptomatic treatment | Usual Care | Other |
I/C | Plasma (and variants) | Cellular & Gene | |
I/C | Non-convalescent Plasma | Blood Plasma | Cellular & Gene |
I/C | Support or Supportive Care | Support | Other |
I/C | Liberal oxygen therapy | High Dose | Pharmacological |
I/C | Conservative oxygen therapy | Low Dose | Pharmacological |
O | Response rate | Therapeutic Response | Physiological or clinical |
O | Clinical response | Therapeutic Response | Physiological or clinical |
O | Response to treatment | Therapeutic Response | Physiological or clinical |
O | Clinical response to treatment | Therapeutic Response | Physiological or clinical |
O | Response to therapy | Therapeutic Response | Physiological or clinical |
O | Finding related to therapeutic response | Therapeutic Response | Physiological or clinical |
O | Complete response | Therapeutic Response | Physiological or clinical |
O | Blood Routine | Blood Test | Physiological or clinical |
O | Oxygen, ventilation etc (as requirements) | Physiological or clinical | |
O | Viral Load or Viral Cure | Viral Load | Physiological or clinical |
O | Oxygen supply, Oxygen Supplementation, Oxygen Independency etc. | Physiological or clinical | |
O | Hospital or ICU stay/duration of stay/ Admission to ... | Resource use | |
O | 2019-nCOVRNA in gargle | 2019-nCoV RT-PCR | Physiological or clinical |
O | Virus negative conversion | 2019-nCoV RT-PCR | Physiological or clinical |
O | Time for improvement of respiratory symptoms and signs (and similar) | Physiological or clinical | |
O | Time for temperature improvement (and similar) | Physiological or clinical | |
O | Sex-related differences in complications | Sex-related difference AND Complication | Physiological or clinical |
O | Breathing frequency | Rate of Respiration | Physiological or clinical |
O | Immunoglobulin G COVID-19 antibodies | Immunoglobulin G COVID-19 antibodies | Physiological or clinical |
O | Immunoglobulin M COVID-19 antibodies | Immunoglobulin M COVID-19 antibodies | Physiological or clinical |
O | Complete remission of clinical signs of disease | Clinical resolution | Physiological or clinical |
I/C | Quarantine | Behavioural |
Time to ...
Time to Clinical Improvement | https://data.cochrane.org/concepts/1ZAQeEkwo0cpmW |
Time to Clinical Recovery | https://data.cochrane.org/concepts/OW7PMP5pAaCBgR |
Time to defervescence | https://data.cochrane.org/concepts/6nyXkn9P8DIPG3 |
Time to cough | Cough |
Time to Dyspnea | Dyspnea |
Time till the virus nucleic acid test goes negative/ Transition time of novel coronavirus nucleic acid" |
Outcome annotation examples
Study | Outcome | Outcome detail | Annotation |
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NCT04278963 | respiratory progression | Defined as: SPO2≤ 93% on room air or PaO2/FiO2≤ 300mmHg and requirement for supplemental oxygen or more advanced ventilator support | Hypoxia AND (Oxygen therapy OR mechanical ventilation) - all in the same outcome group |