Please note! Commonly used concepts and their categories are being added regularly to Guidance for annotation below.
Workflow
Initial workflow
- Import annotator into CRS Web and test (DL, Metaxis, Deirdre)
- Move from CRS Web test to CRS Web live so team can annotating (Lorne Becker, Anna Last, Deirdre Beecher (Robin Featherstone and Anna Noel-Storr if and when time is available will annotate))
- Initially annotations in live CRS Web will only be viewable in the COVID-19 Study Register UAT
- Anna Last developing vocabulary
- Guidance document to be written up (Deirdre, Anna Last, Lorne Becker)
- From 20/04/2020 others invited to annotate (Liz Stovold, Anne Littlewood, Janne Vendt, and Nai Ming Li. Deirdre may bring in others but this is dependent on how work progresses
- Evaluate time to annotate and various issues which impact on process (Deirdre)
BAU workflow
(yet to be determined/in discussion)
Prioritisation of study type
- Interventional - the annotators mentioned above will annotate these studies
- RCT
- Other
- Diagnostic/Prognostic - being annotated by others
- Observational & other types
Guidance for annotation
(more detailed step by step guidance) Deirdre to insert
Annotation widget
We have imported the annotation widget, that we use for systematic review annotation, in to the CRS Web.
COVID-19 Register in CRS Web
- The register will be listed with any other registers that you access via the CRS Web
- Search and layout is identical to that in other CRS registers
- Additional fields have been added to the CRS records to assist us in our workflow
- Three annotation status are available
Annotation detail required
PICO component | Annotation |
Population/Condition |
|
Intervention |
|
Comparator |
|
Outcomes |
|
Not possible to complete the full annotation?
In some cases you will not be able to complete a full annotation. We ask that you:
- mark the annotation as Complete
- request the missing term(s) in the Slack channel
- in the Annotation Action field in the CRS record select Vocabulary Request
- in the Annotation Notes field take note of the term requested
- as soon as requested term(s) are available modify the annotation
- remove Vocabulary Request
Priority studies to annotate
These may change over time depending on topics to be coved in rapid reviews.
Highest Priority
Intervention Assignment: Randomised and:
Any of the following interventions:
- Hand cleaning with ash
- Convalescent plasma, convalescent serum or convalescent hyperimmune immunoglobulin
- Any intervention in which a core component involves the use of the internet to facilitate video calls or video conferencing through computers, smartphones or tablets
- chloroquine, remdesivir, or corticosteroids
Priority 2
Intervention Assignment: Non-randomised or Unclear or Quasi-randomised and:
Any of the following interventions:
- Hand cleaning with ash
- Convalescent plasma, convalescent serum or convalescent hyperimmune immunoglobulin
- Any intervention in which a core component involves the use of the internet to facilitate video calls or video conferencing through computers, smartphones or tablets
- chloroquine, remdesivir, or corticosteroids
Searching the backlog on https://covid-19.cochrane.org/ to identify priority trials
Restrict to Study Type: Interventional
For the specific interventions:
- Text search for ash*
- Text search for convalescent
- Separate text searches for video, loneliness, "social isolation"
- Separate text searches for chloroquine, remdesivir,
Topics/vocabulary
- Before you start annotating please check that the Cochrane Linked Data Vocabulary to determine whether or not terms are available
- If not available, place your request in the covid19-study-annotation channel in Slack and alert Anna last
Vocabulary notes
Age
A number of studies will state in their inclusion criteria Aged 18 years or older. Please annotate as:
Young Adult 19-24 years or Adult 19-44 years or Middle Aged 45-64 years or Aged 65-79 years or Aged 80 and over 80+ years |
Drug combinations
Use the individual drugs with AND
At Risk Of
In some studies the inclusion criteria population is 'At risk of ...' - in this case we do not annotate the condition in the Population but only as an Outcome
Table of misc. terms and their categories
PICO | Topic | Domain Term | Category |
---|---|---|---|
I/C | Usual Care | Usual Care | Other |
I/C | Western Medicine | Usual Care | Pharmacological |
I/C | Symptomatic treatment | Usual Care | Other |
I/C | Plasma (and variants) | Cellular & Gene | |
I/C | Non-convalescent Plasma | Blood Plasma | Cellular & Gene |
I/C | Support or Supportive Care | Support | Other |
I/C | Liberal oxygen therapy | High Dose | Pharmacological |
I/C | Conservative oxygen therapy | Low Dose | Pharmacological |
O | Response rate | Therapeutic Response | Physiological or clinical |
O | Clinical response | Therapeutic Response | Physiological or clinical |
O | Response to treatment | Therapeutic Response | Physiological or clinical |
O | Clinical response to treatment | Therapeutic Response | Physiological or clinical |
O | Response to therapy | Therapeutic Response | Physiological or clinical |
O | Finding related to therapeutic response | Therapeutic Response | Physiological or clinical |
O | Complete response | Therapeutic Response | Physiological or clinical |
O | Blood Routine | Blood Test | Physiological or clinical |
O | Oxygen, ventilation etc (as requirements) | Physiological or clinical | |
O | Viral Load or Viral Cure | Viral Load | Physiological or clinical |
O | Oxygen supply, Oxygen Supplementation, Oxygen Independency etc. | Physiological or clinical | |
O | Hospital or ICU stay/duration of stay/ Admission to ... | Resource use | |
O | 2019-nCOVRNA in gargle | 2019-nCoV RT-PCR | Physiological or clinical |
O | Virus negative conversion | 2019-nCoV RT-PCR | Physiological or clinical |
O | Time for improvement of respiratory symptoms and signs (and similar) | Physiological or clinical | |
O | Time for temperature improvement (and similar) | Physiological or clinical | |
O | Sex-related differences in complications | Sex-related difference AND Complication | Physiological or clinical |
O | Breathing frequency | Rate of Respiration | Physiological or clinical |
O | Immunoglobulin G COVID-19 antibodies | Immunoglobulin G COVID-19 antibodies | Physiological or clinical |
O | Immunoglobulin M COVID-19 antibodies | Immunoglobulin M COVID-19 antibodies | Physiological or clinical |
O | Complete remission of clinical signs of disease | Clinical resolution | Physiological or clinical |
I/C | Quarantine | Behavioural |
Time to ...
Time to Clinical Improvement | https://data.cochrane.org/concepts/1ZAQeEkwo0cpmW |
Time to Clinical Recovery | https://data.cochrane.org/concepts/OW7PMP5pAaCBgR |
Time to defervescence | https://data.cochrane.org/concepts/6nyXkn9P8DIPG3 |
Time to cough | Cough |
Time to Dyspnea | Dyspnea |
Time till the virus nucleic acid test goes negative/ Transition time of novel coronavirus nucleic acid" |
Outcome annotation examples
Study | Outcome | Outcome detail | Annotation |
---|---|---|---|
NCT04278963 | respiratory progression | Defined as: SPO2≤ 93% on room air or PaO2/FiO2≤ 300mmHg and requirement for supplemental oxygen or more advanced ventilator support | Hypoxia AND (Oxygen therapy OR mechanical ventilation) - all in the same outcome group |