General information

Tools for COVID-19 annotation

• COVID-19 Study Register 
• CRS Web

• The Cochrane Linked Data Vocabulary

Annotation widget

• We have imported the annotation widget, that we use for systematic review annotation, in to the CRS Web
• If you cannot access the CRS Web please contact Deirdre Beecher

COVID-19Register in CRS Web

• The register will be listed with any other registers that you access via the CRS Web
• Search and layout is identical to that in other CRS registers

Annotation status & fields

• Additional fields have been added to the CRS records to assist us in our workflow

• Three annotation status are available 

Basic steps

1. Search the COVID-19 Register for studies
2. Login to CRS Web
3. Select COVID-19 Register (only applies to those who use multiple registers)
4. Make sure you have ticked IN REGISTER (you do not want to search beyond this)
5. Search for study using the title or study ID
6. Open annotation widget within the record
7. Annotate and Complete!

Annotation detail required

• dosage, schedule etc not required unless is the comparison

Terms not already in vocabulary

• our Vocabulary browser is available HERE

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Priority studies to annotate

For both priority 1 and 2 please search for

• studies with results (journal article or preprint article) then 
• trial registry records

The reference type can be selected on our Study Register

Image Added

Priority 1

Intervention Assignment: Randomised 

Any of the following interventions:

1. Hand cleaning with ash
2. Convalescent plasma, convalescent serum or convalescent hyperimmune immunoglobulin 
3. Any intervention in which a core component involves the use of the internet to facilitate video calls or video conferencing through computers, smartphones or tablets
4. chloroquine, remdesivir, or corticosteroids

Priority 2

Intervention Assignment: Non-randomised or Unclear or Quasi-randomised 

Any of the following interventions:

1. Hand cleaning with ash
2. Convalescent plasma, convalescent serum or convalescent hyperimmune immunoglobulin 
3. Any intervention in which a core component involves the use of the internet to facilitate video calls or video conferencing through computers, smartphones or tablets
4. chloroquine, remdesivir, or corticosteroids

Searching to identify priority trials

• Search on https://covid-19.cochrane.org/ 

1. Restrict to Study Type: Interventional
2. For the specific interventions:
   1. Text search for ash* 
   2. Text search for convalescent
   3. etc.

Topics/vocabulary

• Before you start annotating please check that the Cochrane Linked Data Vocabulary to determine whether or not terms are available
• If not available, place your request in the covid19-study-annotation channel in Slack and alert Anna last

Vocabulary notes

Age

A number of studies will state in their inclusion criteria Aged 18 years or older. Please annotate as:

Drug combinations

Use the individual drugs with AND

At Risk Of

In some studies the inclusion criteria population is 'At risk of ...' - in this case we do not annotate the condition in the Population but only as an Outcome

Table of misc. terms and their categories

Time to ...

Outcome annotation examples