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The P in PICO describes the main characteristics of the participants in a study (sex, age range and condition). When annotating the Population or Participants it is important to consider the question that is the focus of the review.  This is the population group that the intervention will directly affect.

Table of Contents
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Healthy Population

Term

Vocabulary URI

Notes

Healthy

https://data.cochrane.org/concepts/r4hp38frfm0w

Use this term if the authors have stated 'Healthy People' i.e. those who are being assessed for prevention of or at risk of diseases

General population (no specific population)

Condition/Population is not specified

If the population or group is not specified this field should be left empty.

Examples:

CD numberReview titlePopulation as stated in the in the inclusion criteria
CD012805

Aluminium adjuvants used in vaccines versus placebo or no intervention

We will include all trial participants regardless of sex, age, ethnicity, diagnosis, comorbidity, and country of residence.
CD011047

Colchicine for prevention of cardiovascular events

We included trials in adults (aged 18 years and over) with any condition or disease.
CD008077

Slow versus fast subcutaneous heparin injections for prevention of bruising and site pain intensity

We included studies in which participants were males and females 18 years of age or older who were admitted to hospitals or clinics and treated with subcutaneous injections of heparin including LMWH and UFH.

Prevention and Risk

Some reviews look at the prevention of or at risk of a condition. In this case the condition field is left blank will likely be annotated as an outcome.


Expand
titleExamples: prevention of/at risk of


CD

Topic

Annotation

CD010518

Massage therapy for preventing pressure ulcers

  • Population field is empty
  • Pressure ulcers is an Outcome
  • "Preventive" can be added as an Rationale modifier to Massage Therapy in the Intervention section. Click HERE for more info.

CD009551

At risk of invasive aspergillosis

  • Invasive aspergillosis would be an outcome



Two different populations

  • The Population of a review or study sometimes contains two different populations (e.g. parent and child, patient and provider, student and teacher, etc.)
  • The P section in our annotations is set up with the assumption that each P would reflect a single homogeneous group of individuals
  • If P is not clear check the interventions, comparisons or outcomes to determine who is the target of the intervention, or will have outcome measurements performed


Expand
titleExamples of where two populations can cause confusion


Populations

Description

How to annotate

Pregnant women

  • During pregnancy, any intervention delivered to the mother has the potential to affect the fetus
  • Some authors will reflect this by stating "pregnant women and their unborn children" or some similar formulation as the P
  • Some of these reviews or studies will measure outcomes in both mothers and fetus
  • In most cases it is safe to include only information about the mother in the P and allow the Pregnancy part of the annotation to indicate that a fetus is also involved

Indirect interventions

  • In some studies an intervention directed at one group is intended to have an impact on a different group and authors include both the target and the vector in their description of P
  • The target of the intervention should be used as the P and the group through which the intervention is delivered can be left un-annotated 

Study design

  • Information about how study subjects were recruited is sometimes included but may look like 2 Ps rather than one
  • A study that asked physicians to recruit patients might list the P as "patients with X and their physicians"
  • Do not annotate the physician if their only role was recruitment as they will not be the target of the interventions or have outcome measurements performed
Expand
titleExample


CD number

Title

Types of participants

Notes

CD010385

Strategies of testing for syphilis during pregnancy

Eligible participants were either pregnant women at any stage of their pregnancy or healthcare facilities/clinics depending on the randomisation unit in each of the included trials

  • Who is the intervention directed towards? Clearly the pregnant women were the P, because healthcare facilities/clinics never get antenatal syphilis screening tests.  
  • So the healthcare facilities/clinics part can be ignored in the annotation.



Two populations

  • Some studies or reviews look at intervention effects in two or more populations
  • Use OR





Sex (gender)

  • Annotate the specific sex stated in the review
  • If none is is stated select male and female except where it may be obvious that the sex is one or the other, e.g. Pregnancy.

Age

  • The age groupings have been taken from MeSH
  • Some groupings may not reflect precisely the specific age group stated in the review e.g. authors may state adults from 20 to 35 years of age for which the annotator would need to select Adult 19-44
  • Adolescent is listed under 'Child'. Under Adult we have Young Adult Years (19-24) and Adult (19-44)
  • A number of studies will state in their inclusion criteria Aged 18 years or older. Please annotate as Adult & Aged (or select the specific group(s) within each category) as required.

Expand
titleAge groupings - click here to expand


Age groupingsImage
Infant

Child

Adolescent
Adult

Aged





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