Versions Compared

Key

  • This line was added.
  • This line was removed.
  • Formatting was changed.


Info
titlePlease note!

Commonly used concepts and their categories are being added regularly to tables in this guidance document

Table of Contents



Basic steps

Each step is hyperlinked to a brief demo video.

  1. Search the

General information

Annotation widget

  • We have imported the annotation widget, that we use for systematic review annotation, in to the CRS Web
  • If you cannot access the CRS Web please contact Deirdre Beecher
  1. COVID-19 Register
in CRS Web
  • The register will be listed with any other registers that you access via the CRS Web
  • Search and layout is identical to that in other CRS registers

Annotation status & fields

  • Additional fields have been added to the CRS records to assist us in our workflow
Expand
titleClick here to view additional fields
FieldDescriptionAnnotated by

 when an annotation is completed this field will be autofilled with the users name

Annotator action

there are two options here, In Progress or Vocabulary Request. 

Annotator notesthis is a free text field
  1. for studies
  2. Login to CRS Web & select COVID-19 Register (make sure you have ticked IN REGISTER as you do not want to search beyond this)
  3. Within the CRS Web search for study using the title or study ID
  4. Open annotation widget within the record to annotate

Annotation detail 



Required

Not requiredNotes
Population/Condition
  • Sex
  • Age 
  • Condition



Intervention
  • Three annotation status are available 
Expand
titleClick here for list ot status

Status

Description

Available for annotation

record is available for anyone to annotate

Annotating 

the record is open and being annotated by another person

Annotated 

annotation has been completed

Annotation detail required

  • Sex
  • Age 
  • Condition &

    Population/Condition

    InterventionComparatorOutcomes
    • Drug/Material/Procedure
    • Category
    • dosage
    • schedule
    • units
    If the study is comparing dosage please insert this data
    Comparator
    • Drug/Material/Procedure
    • Category heading



    Outcomes
    • Primary
    • Secondary
    • Category heading
    • endpoints
    For each outcome create a new group

    Terms not already in vocabulary

    • our Vocabulary browser is available HERE
    Info
    titleNot possible to complete the full annotation?

    In some cases you will not be able to complete a full annotation. We ask that you:

    1. mark the annotation as Complete
    2. in the Annotation Action field in the CRS record select Vocabulary Request
    3. in the Annotation Notes field take note of the term requested
    4. request the missing term(s) in the Slack channel alerting Anna Last
    5. as soon as requested term(s) are available modify the annotation
    6. remove Vocabulary Request action
    7. remove the term requested from the Annotation Notes field


    HTML
    <a href="#com-atlassian-confluence">Back to Top</a>

    Priority studies to annotate

    Info
    titleImportant!

    These may change over time depending on topics to be coved in rapid reviews.

    Highest Priority

    Intervention Assignment: Randomised and:

    Any of the following interventions:

    1. Hand cleaning with ash
    2. Convalescent plasma, convalescent serum or convalescent hyperimmune immunoglobulin 
    3. Any intervention in which a core component involves the use of the internet to facilitate video calls or video conferencing through computers, smartphones or tablets
    4. chloroquine, remdesivir, or corticosteroids

    Priority 2

    Intervention Assignment: Non-randomised or Unclear or Quasi-randomised and:

    Any of the following interventions:

    1. Hand cleaning with ash
    2. Convalescent plasma, convalescent serum or convalescent hyperimmune immunoglobulin 
    3. Any intervention in which a core component involves the use of the internet to facilitate video calls or video conferencing through computers, smartphones or tablets
    4. chloroquine, remdesivir, or corticosteroids

    Searching the backlog on https://covid-19.cochrane.org/ to identify priority trials

    Restrict to Study Type: Interventional

    For the specific interventions:

  • Text search for ash* 
  • Text search for convalescent
  • Separate text searches for video, loneliness, "social isolation" 

  • Duplicate study records

    You may come across some duplicate records where the same study has been imported from different sources (e.g. trials registers, pubmed). 

    If you find any:

    • insert the study ID adn state 'duplicate' in the MISC 1 field
    • annotate ONLY one record, preferably the published report (jnl article or preprint)
    Separate text searches for chloroquine, remdesivir, 

    Topics/vocabulary

    • Before you start annotating please check that the Cochrane Linked Data Vocabulary to determine whether or not terms are available
    • If not available, place your request in the covid19-study-annotation channel in Slack and alert Anna last

    Vocabulary notes

    Age

    A number of studies will state in their inclusion criteria Aged 18 years or older. Please annotate as:

    Young Adult 19-24 years or Adult 19-44 years or Middle Aged 45-64 years or Aged 65-79 years or Aged 80 and over 80+ years

    Drug combinations

    Use the individual drugs with AND

    At Risk Of

    In some studies the inclusion criteria population is 'At risk of ...' - in this case we do not annotate the condition in the Population but only as an Outcome.


    Table of misc. terms and their categories

    Table Filter
    id1589544995311_-1310814080


    PICOTopicDomain TermCategory




    I/C

    Usual Care

    Usual CareOther
    I/C

    Western Medicine

    Usual CarePharmacological
    I/C

    Symptomatic treatment

    Usual CareOther
    I/CPlasma (and variants)
    Cellular & Gene
    I/CNon-convalescent PlasmaBlood PlasmaCellular & Gene
    I/CSupport or Supportive CareSupportSupportive CareOther
    I/CLiberal oxygen therapyHigh DosePharmacological
    I/CConservative oxygen therapyLow DosePharmacological
    O

    Response rate

    Therapeutic ResponsePhysiological or clinical
    O

    Clinical response

    Therapeutic ResponsePhysiological or clinical
    O

    Response to treatment

    Therapeutic ResponsePhysiological or clinical
    O

    Clinical response to treatment

    Therapeutic ResponsePhysiological or clinical
    O

    Response to therapy

    Therapeutic ResponsePhysiological or clinical
    O

    Finding related to therapeutic response

    Therapeutic ResponsePhysiological or clinical
    O

    Complete response

    Therapeutic ResponsePhysiological or clinical
    O

    Blood Routine

    Blood TestPhysiological or clinical
    OOxygen, ventilation etc (as requirements)
    Physiological or clinical

    O

    Viral Load or Viral Cure

    Viral LoadPhysiological or clinical
    OOxygen supply, Oxygen Supplementation, Oxygen Independency etc.

    Oxygen Supplementation

    Physiological or clinical
    OHospital or ICU stay/duration of stay/ Admission to ...
    Resource use
    O2019-nCOVRNA in gargle 2019-nCoV RT-PCRPhysiological or clinical
    OVirus negative conversion2019-nCoV RT-PCRPhysiological or clinical
    OTime for improvement of respiratory symptoms and signs (and similar)

    Clinical Improvement or 

    Time to clinical improvement

    Physiological or clinical
    OTime for temperature improvement (and similar)

    Clinical Improvement or 

    Time to clinical improvement

    Physiological or clinical
    OSex-related differences in complicationsSex-related difference AND ComplicationPhysiological or clinical
    OBreathing frequencyRate of RespirationPhysiological or clinical
    OImmunoglobulin G COVID-19 antibodiesImmunoglobulin G COVID-19 antibodiesPhysiological or clinical
    OImmunoglobulin M COVID-19 antibodiesImmunoglobulin M COVID-19 antibodiesPhysiological or clinical
    OComplete remission of clinical signs of diseaseClinical resolutionPhysiological or clinical
    I/CQuarantineQuarantineBehavioural
    ODuration of ICU StayLength of ICU StayResource Use
    OPlasma ViscosityPlasma viscosity measurement Physiological or clinical
    OSerum TNF-alpha level

    Tumour Necrosis Factor Level

    Physiological or clinical


    Time to ...

    Time to Clinical Improvementhttps://data.cochrane.org/concepts/1ZAQeEkwo0cpmW
    Time to Clinical Recoveryhttps://data.cochrane.org/concepts/OW7PMP5pAaCBgR
    Time to defervescencehttps://data.cochrane.org/concepts/6nyXkn9P8DIPG3
    Time to cough Cough
    Time to Dyspnea Dyspnea

    Time till the virus nucleic acid test goes negative/

    Transition time of novel coronavirus nucleic acid"

    2019-nCoV RT-PCR


    Outcome annotation examples

    StudyOutcomeOutcome detailAnnotation
    NCT04278963respiratory progressionDefined as: SPO2≤ 93% on room air or PaO2/FiO2≤ 300mmHg and requirement for supplemental oxygen or more advanced ventilator support Hypoxia AND (Oxygen therapy OR mechanical ventilation) - all in the same outcome group
    HTML<a href="#com-atlassian-confluence">Back to Top</a>