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Whatourthe Vocabulary browser provides | ||
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| 1 | Number of systematic reviews which have been annotated with the terms in the vocabulary |
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| 2 | Vocabularies from where the term has been taken | |
| 3 | The parent or broader terms | |
| 4 | The child or narrower terms | |
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MedDRA | |
WHO ATC/DDD |
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RxNorm |
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SNOMED CT |
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Which
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vocabularies are relevant to P, I, C, or O?
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Many of the terms used in the Conditions section of P are also applicable to outcomes. Therefore, the same controlled vocabulary terms that are available in P (MedDRA and portions of SNOMED CT) are used used for Outcomes.
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Synonyms and near synonyms in the controlled
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vocabularies
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When synonyms or near-synonyms appear in the controlled vocabularies, then the following processes will be followed to standardize annotations. |
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MedDRA has been structured so that every term at the second-lowest level of its hierarchy (PT - Preferred Term) has a synonymous term at its lowest level (LLT - Lowest Level Term). The LLT member of each of these pairs has been removed from the Cochrane Vocabularyvocabulary, so there should be no exactly identical terms from MedDRA. If you uncover any examples in the course of annotation or QA, please send a Merge request via the Vocabulary Request form on your Review Group page. However, there may be other close matches within MedDRA; for example, UK and US spellings of a term (oedema, edema etc.) are separate terms in MedDRA. This will be resolved in a way that will merge these MedDRA synonyms.
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- If one of the MedDRA synonyms is linked to a SNOMED term, pick that one.
- Annotate using the more frequently used term. If needed, send a Preferred Term Selection request via the Vocabulary Request form on your Review Group page.
- If a UK spelling exists, please use it. If you do find US spellings, request a Merge of these terms via the Vocabulary Request form on your Review Group page.If neither of the above exists, just pick any one of a group of MedDRA terms that seem to be synonyms and we will be able to merge your annotation with annotations using one of the other terms.
WHO ATC
Duplication arising from different formulations of the same drug
WHO ATC is organized by organ system, so a drug that is used in different formulation for different body systems will have multiple entries in the original WHO vocabulary (e.g. tetracycline formulations for application to the skin have a term that starts with D (dermatologic), those for use in eyes or ears have an S (sensory), in the mouth it's A (alimentary) etc.) We have The Linked Data team has merged all of these terms into a single Cochrane tetracycline term and merged it with related terms from RxNorm and SNOMED CT - so tetracylcline is now mapped to
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The WHO drug categories are organised by organ system, and WHO has chosen to give identical labels or labels that appear synonymous to drug categories in different (organ system) parts of their vocabulary.
the The parent terms for Tetracycline include Tetracyclines, Antiinfectives, Antibiotics, and a second Antiinfectives and these categories are based on organ systems. The two Antiinfective terms, for example, apply to tetracycline eye or ear drops, so would not be an appropriate choice for an annotation of systemic anti-infectives. We are The LInked Data team is working to relabel the WHO drug categories to make these distinctions clearer, but if there are apparent synonyms, the correct term can be chosen by looking at the initial letter in the WHO identifier.
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A term in one vocabulary has a synonymous term in a different vocabulary
MedDRA and SNOMED CT
We have The Linked Data team has attempted to identify all cases in which a term in MedDRA has a label that is identical to the label from a term in SNOMED CT and these have been merged into a single Cochrane term - with both parent terms listed in the the our various tools whenever the term is used.
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If you find examples of near synonyms in these 2 two vocabularies in the course of annotation or QA, please flag them up for us to resolve. Our send a Merge request via the Vocabulary Request form on your Review Group page. The plan is to either combine them into a single Cochrane term (as above) or to designate one of the pair as a "Cochrane Preferred Term" to be used in all relevant annotations.
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