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Terms for the "Condition" portion of P are drawn from two standard vocabularies - MedDRA and SNOMED CT. All of the terms from MedDRA are available for P annotation, but only selected subsets of SNOMED have been included. If you find term in SNOMED CT that you feel would be applicable for annotation of a Condition, but you cannot access the term in the P part of the PICO annotator, please request it via the Vocabulary Request form on your Review Group Confluene page.
Vocabularies for I and C
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If you find a term in SNOMED that you feel would be applicable for annotation of a non-drug intervention, but you cannot access the term in the I or C part of the PICO annotator, please request it via the Vocabulary Request form on your Confluence Review Group page. |
Vocabularies for O
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MedDRA has been structured so that every term at the second-lowest level of its hierarchy (PT - Preferred Term) has a synonymous term at it's its lowest level (LLT - Lowest Level Term). The LLT member of each of these pairs has been removed from our the Cochrane Vocabulary, so there should be no exactly identical terms within from MedDRA. Update: most of these synonymous terms have been removed, but if If you uncover any examples in the course of annotation or QA, please send a Merge request via the Vocabulary Request form on your Review Group page. However, there will may be many other close matches within MedDRA; for example, UK and US spellings of a term (oedema, edema etc.) are separate terms in MedDRA. This will be resolved in a way that will merge these MedDRA synonyms.
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- If one of the MedDRA synonyms is linked to a SNOMED term, pick that one.
- If a UK spelling exists, please use it. If you do find US spellings, request a Merge of these terms via the Vocabulary Request form on your Confluence Review Group page.
- If neither of the above exists, just pick any one of a group of MedDRA terms that seem to be synonyms and we will be able to merge your annotation with annotations using one of the other terms.
WHO ATC
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Duplication arising from different formulations of the same drug
WHO-WHO ATC is organized by organ system, so a drug that is used in different formulation for different body systems will have multiple entries in the original WHO vocabulary (e.g. tetracycline formulations for application to the skin have a term that starts with D (dermatologic), those for use in eyes or ears have an S (sensory), in the mouth it's A (alimentary) etc.) We have merged all of these terms into a single Cochrane tetracycline term and merged it with related terms from RxNorm and SNOMED CT - so tetracylcline is now mapped to
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