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The terms for drug interventions come from from the following vocabularies:
- RxNorm, RxNorm
- WHO ATC
- SNOMED CT
Drug categories
We are only using WHO ATC and SNOMED CT for are used for drug categories.
Many interventions (especially at the review level) are are drug categories rather than a single agent - antibiotics, vitamins, analgesics, etc. RxNorm only lists individual drugs or drug combinations and has no codes for drug categories.
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Non-drug interventions
Terms for all non-drug interventions are drawn from SNOMED CT. As with P, we have included only selected subsets of this vocabulary are included in the Cochrane vocabulary.
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If you find a term in SNOMED that you feel would be applicable for annotation of a non-drug intervention, but you cannot access the term in the I or C part of the PICO annotator, please flag it as a vocabulary issue so that we can investigate the possibility of adding it (along with related terms)request it via the Vocabulary Request form on your Confluence Review Group page. |
Vocabularies for O
Many of the terms used in the Conditions section of P are also applicable to outcomes. Therefore, the same controlled vocabulary terms that are available in P (MedDRA and portions of SNOMED CT) are used for Outcomes.
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Synonyms and near synonyms in the
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controlled Vocabularies
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Where When synonyms or near-synonyms appear in the controlled vocabularies that we will use , then the following processes will be followed to standardize annotations (as much as possible). |
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There is now a type-ahead function in the PICO annotator that shows the frequency of term use (i.e. the number of times a term has been used by annotators is displayed immediately after each term in the drop-down menu for each PICO component). |
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A term in one vocabulary has a synonymous term in the same vocabulary
MedDRA
For some reason, MedDRA has been structured so that every term at the second-lowest level of its hierarchy (PT - Preferred Term) has a synonymous term at it's lowest level (LLT - Lowest Level Term). The LLT member of each of these pairs has been removed from our Cochrane Vocabulary, so there should be no exactly identical terms within MedDRA. Update: most of these synonymous terms have been removed, but if you uncover any examples in the course of annotation or QA, please send a vocabulary Merge request via the Vocabulary Request form on your Review Group page. However, there will be many close matches within MedDRA - ; for example, UK and US spellings of a term (oedema, edema etc.) are separate terms in MedDRA. This will be resolved in a way that will merge these MedDRA synonyms.
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- If one of the MedDRA synonyms is linked to a SNOMED term, pick that one.
- If a UK spelling exists, please use it. . If you do find US spellings, request a Merge of these terms via the Vocabulary Request form on your Confluence Review Group page.
- If neither of the above exists, just pick any one of a group of MedDRA terms that seem to be synonyms and we will be able to merge your annotation with annotations using one of the other terms.
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