Basic steps
Each step is hyperlinked to a brief demo video.
- Search the COVID-19 Register for studies
- Login to CRS Web & select COVID-19 Register (make sure you have ticked IN REGISTER as you do not want to search beyond this)
- Within the CRS Web search for study using the title or study ID
- Open annotation widget within the record to annotate
Annotation detail required
Population/Condition | Intervention | Comparator | Outcomes |
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- dosage, schedule etc not required unless is the comparison
Terms not already in vocabulary
- our Vocabulary browser is available HERE
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In some cases you will not be able to complete a full annotation. We ask that you:
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<a href="#com-atlassian-confluence">Back to Top</a> |
Priority studies to annotate
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These may change over time depending on topics to be coved in rapid reviews. |
For both priority 1 and 2 please search for
- studies with results (journal article or preprint article) then
- trial registry records
The reference type can be selected on our Study Register
Priority 1
Limit search to
- Study Reference Type: Journal Article/Preprint Article
- Intervention Assignment: Randomised
Any of the following interventions:
- Hand cleaning with ash
- Convalescent plasma, convalescent serum or convalescent hyperimmune immunoglobulin
- Any intervention in which a core component involves the use of the internet to facilitate video calls or video conferencing through computers, smartphones or tablets
- chloroquine, remdesivir, or corticosteroids
Priority 2
- Study Reference Type: Journal Article/Preprint Article
- Intervention Assignment: Non-randomised or Unclear or Quasi-randomised
Any of the following interventions:
- Hand cleaning with ash
- Convalescent plasma, convalescent serum or convalescent hyperimmune immunoglobulin
- Any intervention in which a core component involves the use of the internet to facilitate video calls or video conferencing through computers, smartphones or tablets
- chloroquine, remdesivir, or corticosteroids
Searching to identify priority trials
- Search on https://covid-19.cochrane.org/
- Restrict to Study Type: Interventional
- For the specific interventions:
- Text search for ash*
- Text search for convalescent
- etc.
Duplicate study records
You may come across some duplicate records where the same study has been imported from different sources (e.g. trials registers, pubmed).
If you find any:
- insert the study ID adn state 'duplicate' in the MISC 1 field
- annotate ONLY one record, preferably the published report (jnl article or preprint)
Topics/vocabulary
- Before you start annotating please check that the Cochrane Linked Data Vocabulary to determine whether or not terms are available
- If not available, place your request in the covid19-study-annotation channel in Slack and alert Anna last
Vocabulary notes
Age
A number of studies will state in their inclusion criteria Aged 18 years or older. Please annotate as:
Young Adult 19-24 years or Adult 19-44 years or Middle Aged 45-64 years or Aged 65-79 years or Aged 80 and over 80+ years |
Drug combinations
Use the individual drugs with AND
At Risk Of
In some studies the inclusion criteria population is 'At risk of ...' - in this case we do not annotate the condition in the Population but only as an Outcome.
Table of misc. terms and their categories
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Time to ...
Time to Clinical Improvement | https://data.cochrane.org/concepts/1ZAQeEkwo0cpmW |
Time to Clinical Recovery | https://data.cochrane.org/concepts/OW7PMP5pAaCBgR |
Time to defervescence | https://data.cochrane.org/concepts/6nyXkn9P8DIPG3 |
Time to cough | Cough |
Time to Dyspnea | Dyspnea |
Time till the virus nucleic acid test goes negative/ Transition time of novel coronavirus nucleic acid" |
Outcome annotation examples
Study | Outcome | Outcome detail | Annotation |
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NCT04278963 | respiratory progression | Defined as: SPO2≤ 93% on room air or PaO2/FiO2≤ 300mmHg and requirement for supplemental oxygen or more advanced ventilator support | Hypoxia AND (Oxygen therapy OR mechanical ventilation) - all in the same outcome group |